Peptides

The treatment of cancer is possible with a variety of procedures and medications, and many more are currently being studied. Cancer treatment options are divided into “local” and “systemic” treatments. Surgery and therapy are examples of the “local” cancer treatment used for treating a particular tumor or area of the body. In turn, “systemic” treatment […]

Currently, neurodegenerative disorders treatment is based on the use of mesenchymal stem cells (MSCs). The progression of the disease is manifested by neuronal death and the afterward loss of brain and cognitive functions. MSCs are likely acting by stimulating many physiological processes, including angiogenesis and neurogenesis. Furthermore, MSCs possess a vital role in the immunomodulatory, […]

Alzheimer’s disease is a neurodegenerative disease that affects older adults and causes dementia. Progressive cognitive impairment is a hallmark of this condition. Globally, AD incidence is growing exponentially. According to predictions, the number of people with dementia will increase to 131.5 million across the globe by 2050. Alzheimer’s disease comes in several forms, the most […]

Digestive system Such short-chain Khavinson peptides as Epitalon, Livagen, and Vilon are not cleaved in the stomach and small intestine. They can regulate digestive enzyme activities in animals. The administration of Livagen and Vilon increased digestive enzymes activities in aged animals to a level that is typical for young animals. In addition, the peroral administration […]

What are short-chain Khavinson peptides? Vladimir Khavinson developed a method of invention short-chain peptides based on the analysis of the amino acid composition of animal tissue peptide extract. These short-chain peptides have the main in vivo and in vitro activities of the preparations described above.The principles of designing biologically active short-chain Khavinson peptides include: the […]

Epithalamin is a peptide complex derived from the bovine pineal gland. It is used to treat accelerated cardiovascular aging in older adults. Studies showed that Epithalamin administration decreased aging and mortality rate over 15 years of follow-up. In addition, the long-term use of this peptide complex reduces the rate of cardiovascular system aging, restores physical […]

Cortexin is a peptide complex isolated from the brain cortex of cattle or hogs. It shows a prominent neuroprotective effect, stimulating repair processes in the brain and accelerating the recovery of brain function after stress. Effects of Cortexin The administration of Cortexin to patients with the organic emotionally labile (asthenic) disorder resulted in decreased blood […]

Since 1973, the team of V.Kh. Khavinson and colleagues have isolated more than 20 physiologically active substances comprised mainly of small peptides. These compounds were obtained from mammalian tissues. Five of them have been approved for medical use, including: Cortexin derived from the brain cortex Eipthalamin derived from the pineal gland Prostatilen derived from the […]

Our gut is one of the sources of regulatory peptides. It does not contribute significantly to the production of long molecules. However, it is of great significance when it comes to short-chain peptides. Peptides appear in the intestinal lumen due to either degradation of food proteins or synthetic activity of intestinal microbiota. Every day, we […]

Receptor-mediated interactions Despite the significant pharmaceutical interest in the details of regulatory Khavinson peptides interactions with their specific receptors on cell membranes, much of the details remain unclear. Information on the binding of about a dozen of peptides to receptors embedded in dodecylphosphocholine micelles proposes that: a ligand might interact with the lipid bilayer around […]